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Publications
Patent
Patent "Application of 19F MR to non-invasively assess pO2 and temperature in vivo with rapid time resolution", R. P. Mason & P.P. Antich, US patent No. 5,397,562, March 1995, licensed to AMI 2000.
a) Investigative Reports (Peer Reviewed Publications) 1. "Trans alkenes by stereoselective reduction of -Ph2PO ketones," A. D. Buss, R. P. Mason & S. G. Warren, Tet. Lett., 24, 5293-5296 (1983) 2. "NMR visualisation of free asparagine in potato tissue using adduct formation with 13C formaldehyde in situ ," R. P. Mason, J. K. M. Sanders & M. J. Gidley, Phytochem., 25, 1567-1571 (l986) 3. "Formaldehyde metabolism by E. Coli: detection using in vivo13C NMR spectroscopy of S-(hydroxymethyl) glutathione as a transient intracellular intermediate," R. P. Mason, J. K. M. Sanders, A. Crawford & B. K. Hunter, Biochemistry, 25, 4504-4507 (l986) 4. "Application of stereochemically controlled Horner-Wittig reactions: synthesis of feniculin, E-non-6-en-l-ol, a pheromone of the Mediterranean fruit fly, E and Z-dec-5-en-l-ol, trisubstituted alkenes and Z-a-bisabolene," A. D. Buss, N. Greeves, R. P. Mason & S. G. Warren, J. Chem. Soc. Perkin Trans l, 2569-2577 (1987) 5. "In vivo enzymology: 13C NMR measurement of kinetic isotope effect for methanol oxidation in Methylosinus trichosporium OB3b," R. P. Mason, J. K. M. Sanders & A. C. Cornish, FEBS Letters, 216, 4-6 (l987) 6. "Formaldehyde adducts of glutathione: structure elucidation by 2-D NMR spectroscopy and fast atom bombardment tandem mass spectrometry." S. Naylor, R. P. Mason, J. K. M. Sanders, D. H. Williams & G. Moneti, Biochem. J., 249, 573-579 (l988) 7. "In vivo enzymology: a deuterium NMR study of formaldehyde dismutase in Pseudomonas putida F61a and Staphylococcus aureus", R. P. Mason & J. K. M. Sanders, Biochemistry, 28, 2160-2168 (1989) 8. "Perfluorocarbon imaging in vivo: a 19F MRI study of tumor bearing mice, R. P. Mason, P. P. Antich, E. E. Babcock, J. L. Gerberich, & R. L. Nunnally. Magn. Reson. Imaging, 7 (5), 475-485 (l989) 9. "Applications of magnetic resonance techniques to deep tumor hyperthermia", P. P. Antich, R. P. Mason, & R. L. Nunnally, Strahlenther. u. Onkol., 165, 734-737 (1989) 10. "A novel editing technique for 19F MRI: Molecule specific imaging", R. P. Mason, N. Bansal, E. E. Babcock, R. L. Nunnally & P. P. Antich, Magn. Reson. Imaging, 8, 729-736,(1990) 11. "Effect of Homonuclear J-modulation on 19F spin-echo images", E. E. Babcock, R. P. Mason, & P. P. Antich, Magn. Reson. Med., 17, 179-188 (1991) "Tissue oxygen tension: a novel determination using 19F surface coil nmr spectroscopy of sequestered perfluorocarbon emulsion", R. P. Mason, R. L. Nunnally, & P. P. Antich, Magn. Reson. Med., 18, 71-79 (1991) 13. "Novel molecular probes for 19F MRI: synthesis & characterization of fluorinated polymers",V. D. Mehta, P. V. Kulkarni, S. B. Rajur, R. P. Mason, E. E. Babcock, A. Constantinescu, & P. P. Antich, BioMed. Chem. Letters , 2, 527-532 (1992) 14. "Oxygent: a novel probe of tissue oxygen tension", R. P. Mason, H. Shukla, & P. P. Antich, Biomater. Artif. Cells Immob. Biotechnol., 20, 929-932 (1992) 15. "A non-invasive assessment of myocardial oxygen tension: 19F NMR spectroscopy of sequestered perfluorocarbon emulsion", R. P. Mason, F. M. H. Jeffrey, C. R. Malloy, E. E. Babcock & P. P. Antich, Magn. Reson. Med., 27, 310-317 (1992) 16. "Glutathione in whole blood: a novel determination using double quantum coherence transfer proton NMR spectroscopy", R. P. Mason, G. H. Cha, G. H. Gorrie, E. E. Babcock & P. P. Antich, FEBS Letters, 318(1), 30-34 (1993) 17. "Fluorinated macromolecular probes for non-invasive assessment of pH by magnetic resonance spectroscopy", V. D. Mehta, P. V. Kulkarni, R. P. Mason, & P. P. Antich, BioMed. Chem. Letters, 3, 187-192 (1993) 18. "In vivo oxygen tension and temperature: simultaneous determination using 19F NMR spectroscopy of perfluorocarbon", R. P. Mason, H. Shukla & P. P. Antich, Magn. Reson. Med., 29, 296-302 (1993) 19."Isolated tumor growth in a surgically formed skin pedicle in the rat: a new tumor model for NMR studies” E. W. Hahn, P. Peschke, R. P. Mason, E. E. Babcock, & P. P. Antich, Magn. Reson. Imaging, 11, 1007-1017 (1993) 20. "Echo-planar imaging of perfluorocarbons", B. R. Barker, R. P. Mason & R. M. Peshock, Magn. Reson. Imaging, 11(8),1165-73 (1993) 21. "Non-Invasive Determination of Tumor Oxygen Tension and Local Variation with Growth" R. P. Mason, P. P. Antich, E. E. Babcock, A. Constantinescu, P. Peschke & E. W. Hahn, Int. J. Radiat. Oncol. Biol. Phys. 29 (1), 95-103 (1994) 22. "Fluorinated proteins as potential 19F MRI and spectroscopy agents, V. D. Mehta, P. V. Kulkarni, R. P. Mason, A. Constantinescu & P. P. Antich, Bioconj. Chem. 5(3), 257-261 (1994). 23. "Oxygen Tension Mapping by 19F Echo Planar NMR Imaging of Sequestered Perfluorocarbon", B. R. Barker, R. P. Mason, N. Bansal, & R. M. Peshock, JMRI 4, 595-602 (1994). 24. " 6-Fluoropyridoxol: a novel probe of cellular pH using 19F NMR spectroscopy", V. D. Mehta, P. V. Kulkarni, R. P. Mason, A. Constantinescu, S. Aravind, N. Goomer, & P. P. Antich, FEBS Letters, 349, 234-238 (1994). 25. "Non-invasive physiology: 19F NMR of perfluorocarbons", R. P. Mason, Artif. Cells Blood Subs. Immob. Biotechnol., 22, 1141-1153 (1994) 26. "Tumor oxygen tension: measurement using Oxygent TM as a 19F NMR probe at 4.7 T", R. P. Mason & P. P. Antich, Artif. Cells Blood Subs. Immob. Biotechnol., 22, 1361-1367 (1994) 27. "A comparison of three commercial perfluorocarbon emulsions as high field NMR probes of oxygen tension and temperature", H. P. Shukla, R. P. Mason, D. E. Woessner & P. P. Antich, J. Magn. Reson. B, 106, 131-141 (1995). 28. "Regional Myocardial Oxygen Tension: 19F MRI of Sequestered Perfluorocarbon", H. P. Shukla, R. P. Mason, N. Bansal & P. P. Antich, Magn. Reson. Med., 35, 827-833 (1996). 29. "Hexafluorobenzene: a sensitive 19F NMR indicator of tumor oxygenation". R.P. Mason, W. Rodbumrung, & P. P. Antich, NMR in Biomed. 9, 125-134 (1996). 30. "6-Fluoropyridoxal polymer conjugates: novel 19F pH indicators for magnetic resonance spectroscopy", V. D. Mehta, S. Aravind, P. V. Kulkarni, R.P. Mason, & P. P. Antich, Bioconj. Chem. 7, 536-540 (1996). 31. "Regional tumor oxygen dynamics: 19F PBSR EPI of hexafluorobenzene" D. Le, R. P. Mason, S. Hunjan, A. Constantinescu, B. R. Barker & P. P. Antich. Magn. Reson. Imaging, 15 (8) 971-81 (1997) 32. "Connectivity in human cancellous bone by 3D MRI Microscopy", M. Wessels, R. P. Mason, P. P. Antich, J. E. Zerwekh and C. Y. C. Pak Med. Phys. 24 (9), 1409-1420 (1997) 33. "Simultaneous intra- and extra- cellular pH measurement using 19F NMR of 6-Fluoropyridoxol", S. Hunjan, R. P. Mason, V. D. Mehta, P. V. Kulkarni, S. Aravind, V. Arora & P. P. Antich, Magn. Reson. Med., 39, 551-556 (1998) 34. "Regional Tumor Oximetry: 19F NMR Spectroscopy of Hexafluorobenzene", S. Hunjan, R. P. Mason, A. Constantinescu, P. Peschke, E. W. Hahn & P. P. Antich, Int. J. Radiat. Oncol. Biol. Phys. 41 (1) 161-171 (1998). 35. "Development of Novel 19F NMR pH Indicators: Synthesis and Evaluation of a Series of Fluorinated Vitamin B6 Analogs" S. He, R. P. Mason, S. Hunjan, V. D. Mehta, V. Arora, R. Katipally, P. V. Kulkarni, and P. P. Antich, BioOrg. Med. Chem. 6, 1631-1639 (1998) 36 "Regional Tumor Oxygen Tension: Fluorine Echo Planar Imaging of Hexafluorobenzene Reveals Heterogeneity of Dynamics" R. P. Mason, S. Hunjan, D. Le, A. Constantinescu, B. R. Barker, P. S. Wong, P. Peschke, E. W. Hahn, and P. P. Antich, Int. J. Radiat. Oncol. Biol. Phys. 42, 4 , 747-50 (1998) 37. "Transmembrane pH gradients in vivo: measurements using fluorinated vitamin B6 derivatives" R. P. Mason, Curr. Med. Chem. 6, 533-51 (1999) 38. "Regional tumor oxygenation and measurement of dynamic changes" R. P. Mason, A. Constantinescu, S. Hunjan, D. Le, E. W. Hahn, P. P. Antich, C. Blum and P. Peschke, Radiat Res. 152, 239-249 (1999) 39. “Noninvasive Investigation of Blood Oxygenation Dynamics of Tumors by Near-Infrared Spectroscopy” H. Liu, Y. Song, K. L. Worden, X. Jiang, A. Constantinescu, & R. P. Mason, Appl. Optics, 39 (28) 5231-43 (2000) 40. "Tumor Oximetry: demonstration of an enhanced dynamic mapping procedure using fluorine-19 echo planar magnetic resonance imaging in the Dunning prostate R3327-AT1 rat tumor” S. Hunjan, D. Zhao, A. Constantinescu, E. W. Hahn, P. P. Antich, & R. P. Mason, Int. J. Radiat. Oncol. Biol. Phys., 49 (4), 1097-1108 (2001). 41. “Prognostic Radiology: quantitative assessment of tumor oxygen dynamics by MRI”, D. Zhao, A. Constantinescu, L. Jiang, E. W. Hahn and R. P. Mason, Am. J. Clin. Oncol., 24, 462-466 (2001) 42. “Tumor oxygen dynamics with respect to growth and respiratory challenge: investigation of the Dunning prostate R3327-HI tumor”, D. Zhao, A. Constantinescu, E. W. Hahn, and R. P. Mason, Radiat. Res., 156 (5) 510-520 (2001) 43. “Bone Phenotype of the Aromatase Deficient Mouse”, O. K. Öz, G. Hirasawa, J. Lawson, L. Nanu, A. Constantinescu, P. P. Antich, R. P, Mason, E. Tsyganov, R. W. Parkey, J. E. Zerwekh, and E. R. Simpson, J. Steroid Biochem. Molec. Biol. 79, 49-59, (2001) 44. “Differential oxygen dynamics in two diverse Dunning prostate R3327 rat tumor sublines (MAT-Lu and HI) with respect to growth and respiratory challenge”, D. Zhao, A. Constantinescu, E. W. Hahn, R. P. Mason, Int. J. Radiat. Oncol. Biol. Phys., 53 (3), 744-756 (2002) 45. “Quantitative assessment of tumor oxygen dynamics: Molecular Imaging for Prognostic Radiology,” R. P. Mason, S. Ran & P. E. Thorpe, J. Cell. Biochem. 87, 45-53 (2002) 46. “Dynamic Breast tumor oximetry: the development of Prognostic Radiology” Y. Song, A. Constantinescu, & R. P. Mason, Technol. Cancer Res. Treat. 1 (6), 471-8 (2002) 47. “Interplay of Tumor Vascular Oxygenation and Tumor pO2 Observed Using NIRS, Oxygen Needle Electrode, and 19F MR pO2 Mapping”, J. G. Kim, D. Zhao, A. Constantinescu, R. P. Mason, & H. Liu, J. Biomed. Optics, 8 (1), 53-62 (2003) 48. “Correlation of Tumor Oxygen Dynamics with Radiation Response of the Dunning Prostate R3327-HI Tumor”, D. Zhao, A. Constantinescu, C.-H. Chang, E. W. Hahn, & R. P. Mason, Radiat. Res, 159, 621-631 (2003) 49. “Dynamic Response of Breast Tumor Oxygenation to Hyperoxic Respiratory Challenge Monitored with Three Oxygen-Sensitive Parameters” Y. Gu, V. Bourke, J. G. Kim, A. Constantinescu, R. P. Mason, H. Liu, Applied Optics, 42 (16) 1-8 (2003) 50. “Tumor oxygen dynamics: correlation of in vivo MRI with histological findings” D. Zhao, S. Ran, A. Constantinescu, E. W. Hahn & R. P. Mason, Neoplasia, 5 (4) 308-18 (2003) 51. “Molecular imaging in prostate cancer”, J. A. Karam, R. P. Mason, K. S. Koeneman, P. P. Antich, E. A. Benaim, J.-T. Hsieh, J. Cell. Biochem. 90, 473-83 (2003) 52. “A novel NMR approach to assessing gene transfection: 4-fluoro-2-nitrophenyl-b-D-galactopyranoside as a prototype reporter molecule for b-galactosidase”, W. Cui, P. Otten, Y. Li, K. S. Koeneman, J. Yu and R. P. Mason, Magn. Reson. Med., 2004; 51:616-620. 53 “Biodistribution of phosphodiester and phosphorothioate siRNA”. D. A.
Braasch, Zain Paroo, Anca Constantinescu, Gang Ren, Orhan K. Öz, R. P.
Mason,
and D. R. Corey, Bio. Med. Chem. Letters, 14(5):1139-43, 2004 56 “Comparison of BOLD contrast and Gd-DTPA Dynamic Contrast Enhanced imaging in rat prostate tumor”, L. Jiang, D. Zhao, A. Constantinescu and R. P. Mason. Magn. Reson. Med., 51, 953-960 (2004) 57 "A Novel NMR Platform for Detecting Gene Transfection: Synthesis and Evaluation of Fluorinated Phenyl beta-D-Galactosides with Potential Application for Assessing LacZ Gene Expression," J. Yu,P. Otten, Z. Ma, W. Cui, L. Liu, R.P. Mason. Bioconjug. Chem. 2004,15 (6): 1334-1341. 58. "Validating bioluminescence imaging as a high-throughput, quantitative modality for assessing tumor burden," Z. Paroo, R.A. Bollinger, D.A. Braasch, E. Richer, D.R. Corey, P.P. Antich, R.P. Mason. Molecular Imaging, 2004; 3:117-124. 59. “Estimated fraction of tumor vascular blood contents sampled by near infrared spectroscopy and 19F magnetic resonance spectroscopy”, Y. Gu, R. P. Mason, and H. Liu, Optics Express, 13, 1724-1733 (2005). 60. “A New Diagnostic System in Cancer Research: Bioluminescent Imaging (BLI)”, Z. G. Dikmen, G. Gellert, P. Dogan, R.P. Mason, P. Antich, E. Richer, W. E. Wright, J. W. Shay, Turk. J. Med. Sci., 35, 65-70 (2005) 61. “Tumor physiological response to combretastatin A4 phosphate assessed by MRI”, D. Zhao, L. Jiang, E. W. Hahn, and R. P. Mason, Int. J. Radiat. Oncol. Biol. Phys. 62, 872–880 (2005) 62. “Investigation of Rat Breast Tumor Oxygen Consumption by Near Infrared Spectroscopy” Y. Song, J. G. Kim, R. P. Mason, and H. Liu, J. Phys. D: Appl. Phys. 38 2682–2690 (2005) 63. “Continuous low-dose (Metronomic) chemotherapy on rat prostate tumors evaluated using MRI in vivo and comparison with histology”, D. Zhao, L. Jiang, E. W. Hahn, R. P. Mason, Neoplasia, 7(7):678-87 (2005) 64.
“Early
inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces
malignant astrocytoma.” Y. Zhu, F. Guignard, D. Zhao. L. Liu, D.K. Burns, R.P.
Mason. and L.F. Parada. Cancer Cell , 8,
119-130 (2005). 65. "19F: A versatile reporter for non-invasive physiology and pharmacology using magnetic resonance," J. Yu, V.D. Kodibagkar, W. Cui, R.P. Mason. Curr. Med. Chem. 2005, 12, 819-848.
1. "19F MR characterization of fluorinated proteins and relaxation rate enhancement with Gd-DTPA for faster imaging", V. D. Mehta, R. P. Mason, P. V. Kulkarni, P. Lea, A. Constantinescu & P. P. Antich, Proc. Int. Symp. Chemists View of Imaging Centers, (A. H. Emram ed.) Plenum, New York pp305-313 (1995). 2. "Tumor transmembrane pH gradient and regional oxygen tension measured by fluorine magnetic resonance", R. Mason, S. Hunjan, S. He, A. Constantinescu, P. Peschke, E. Hahn and P. Antich, Eds., M. Moraes, R. Brentani, R. Bevilacquas, 17th International Cancer Congress,. Monduzzi, Bologna, pp. 1627-31 (1998). 3. "Tumor Oximetry: A Comparison between Near-Infrared Frequency-Domain Spectroscopy of hemoglobin and 19F MRI of Hexafluorobenzene" K. L. Worden, Y. Song, X. Jiang, A. Constantinescu, R. P. Mason, and H. Liu, SPIE Conf. On Optical Tomography and spectroscopy of tissue III, San Jose, CA, 3597, 601-10 (1999) 4. “Interplay of Tumor Vascular Oxygenation and pO2 in Tumors Using NIRS and Needle Electrode.” J. G. Kim, Y. Song, D. Zhao, A. Constantinescu, R. P. Mason, H. Liu, SPIE Conf. On Optical Tomography and Spectroscopy of Tissue IV, Eds. B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, E. M. Sevick-Muraca, 4250, 429-436 (2001) 5. "Tumor oximetry: comparison of 19F mr epi and electrodes" R. P. Mason, S. Hunjan, A. Constantinescu, Y. Song, D. Zhao, E. W. Hahn, P. P. Antich, and P. Peschke. Oxygen Transport to Tissue XXIV. Proceedings of the 27th annual meeting of the International Society on Oxygen Transport to Tissue. (Dunn, J. F. and H. M. Swartz Eds.) Advances in Experimental Medicine and Biology 530, Kluwer Acad. New York, pp19-28 (2003) 6. “Oxygenation in a human tumor xenograft: manipulation through respiratory challenge and anti-body directed infarction" R. P. Mason, A. Constantinescu, S. Ran and P. E. Thorpe. Oxygen Transport to Tissue XXIV. Proceedings of the 27th annual meeting of the International Society on Oxygen Transport to Tissue. (Dunn, J. F. and H. M. Swartz Eds.) Advances in Experimental Medicine and Biology 530, Kluwer Acad. New York, pp197-204 (2003) 7. "Tumor Oxygen Dynamics: Comparison between 19F MR-EPI of hexafluorobenzene and Frequency Domain NIR Spectroscopy" Y. Song, K. L. Worden, X. Jiang, D. Zhao, A. Constantinescu, H. Liu and R. P. Mason. Oxygen Transport to Tissue XXIV. Proceedings of the 27th annual meeting of the International Society on Oxygen Transport to Tissue. (Dunn, J. F. and H. M. Swartz Eds.), Advances in Experimental Medicine and Biology 530, Kluwer Acad. New York, pp225-236 (2003)
c) Abstracts (Published Conference Proceedings) 1. "NMR estimation of intracellular metabolites by specific adduct formation with infused labeled marker molecules", R. P. Mason & J. K. M. Sanders, Biochem. Soc. Trans., 15, 146-147 (1987) 2. "Approaching enzymic kinetic isotope effects in vivo by NMR", R. P. Mason, J. K. M. Sanders & A. C. Cornish, Biochem. Soc. Trans., 15, 147-148 (1987) 3. "Observation of S-(hydroxymethyl) glutathione in vivo at last!", R. P. Mason & J. K. M. Sanders, Biochem. Soc. Trans., 15, 148-149 (1987) 4. "Tying glutathione in knots" R. P. Mason, S. Naylor, J. K. M. Sanders, D. H. Williams & G. Moneti, Biochem. Soc. Trans., 15, 230-231 (1987) 5. "19F MRI of localization of perfluorocarbons in tumor bearing mice," R. P. Mason, P. P. Antich, E. E. Babcock, J. L. Gerberich & R. L. Nunnally, Proc. Soc. Magn. Reson. Med., New York, 2, 753 (l987) 6. "Tumor imaging by H-l and F-19 NMR," R. P. Mason, P. P. Antich, E. E. Babcock, J. L. Gerberich & R. L. Nunnally, Radiology, 165, 353 (l987) 7. "Metabolic changes during in vivo human tumor xenograft diphtheria-toxin induced cell kill as measured by 31P magnetic resonance spectroscopy," P. P. Antich, G. C. Giovanella, R. P. Mason, R. L. Nunnally, D. F. Ranney & E. P. Frenkel, Proc. AACR, 29, 76 (l988) 8. "Glucose uptake and metabolism by murine tumors: a carbon NMR study," R. P. Mason, P. P. Antich & R. L. Nunnally. Proc. Soc. Magn. Reson. Med., San Francisco, 479, (1988) 9. "Fluosol Adjuvant Therapy in Human Cancer: Examinations in vivo of Perfluorocarbons by F-19 NMR," R. L. Nunnally, P. P. Antich, P. Nguyen, E. E. Babcock, G. M. McDonald & R. P. Mason. Proc. Soc. Magn. Reson. Med., San Francisco, 342 (1988) 10. "Tumor perfusion: a 19F NMR study using the perfluorocarbon Fluosol-DA", R. P. Mason, E. E. Babcock, R. L. Nunnally & P. P. Antich. Proc. XIII ICMRBS, Madison, (1988) 11. "Glucose metabolism in the tumor-bearing mouse," R. P. Mason, R. L. Nunnally & P. P. Antich. Proc. XIII ICMRBS, Madison, (1988) 12. "Nuclear magnetic resonance studies of tumor microcirculation," P. P. Antich, R. P. Mason & R. L. Nunnally, in Magnetic Resonance and Relaxation, Proc. 10th Ampere summer school and symposium, Eds., Bluc, C., Vilfan, M., Slak, J., Ljubljana, 262-262 (1988) 13. "Effect and exploitation of J-modulation in 19F MRI", R. P. Mason, E. E. Babcock, N. Bansal, R. L. Nunnally, & P. P. Antich, Magn. Reson. Imaging, 8(1), 155, (l989) 14. "A non-invasive assessment of myocardial oxygen tension", R. P. Mason, F. M. H. Jeffrey, C. R. Malloy, & P. P. Antich, Soc. Magn. Reson. Med., New York, 1, 176, (1990) 15. "Rapid non-invasive assessment of myocardial pO2 using 19F NMR spectroscopy of sequestered perfluorocarbon emulsion", F. M. H. Jeffrey, R. P. Mason, C. R. Malloy, & P. P. Antich, Circulation, 82(4),III-685, #2722 (1990) 16. "New 19F magnetic resonance imaging agents for drug targeting", V. D. Mehta, P. V. Kulkarni, S. B. Rajur, A. Constantinescu, R. P. Mason, E. E. Babcock, & P. P. Antich, J. Nucl. Med., 32, 1081 (1991) 17. "MRI and MRS of Dunning prostate tumours in the skin pedicle of the Copenhagen rat" P. P. Antich, P. Peschke, R. P. Mason, E. E. Babcock, A. Constantinescu, W. J. Lorenz & E. W. Hahn, p470 in Radiation Research: Proc. 9th Int. Congr. Radiat. Res. vol 1 (Eds. Chapman, Dewey, Whitmore) Academic Press (1991) 18. "Simultaneous oxygen tension and temperature measurements: a novel non-invasive technique", R. P. Mason, & P. P. Antich, p472 in Radiation Research: Proc. 9th Int. Congr. Radiat. Res. vol 1 (Eds. Chapman, Dewey, Whitmore) Academic Press (1991) 19. "Oxygent: a novel probe of tissue oxygen tension", R. P. Mason, H. P. Shukla, & P. P. Antich, Biomater. Artif. Cells Immob. Biotechnol., 19, 430 ( 1991) 20. "In vivo oxygen tension and temperature: simultaneous determination using 19F NMR spectroscopy of perfluorocarbon", R. P. Mason, H. Shukla, & P. P. Antich, Proc Soc. Magn. Reson. Med., San Francisco, 1, 305 (1991) 21. "Fluorinated polymeric molecular probes for non-invasive assessment of pH by magnetic resonance spectroscopy" V. D. Mehta, P. V. Kulkarni, R. P. Mason, G. H. Gorrie & P. P. Antich, J. Nucl. Med., 33(5), 974 (1992) 22. "A Novel Approach to Localized Oxygen Tension Measurements in Tumours: 19F NMR of Sequestered Perfluorocarbon", R. P. Mason, E. E. Babcock, A. Constantinescu, P. Peschke, E. W. Hahn, & P. P. Antich, Proc. 17th LH Gray Conference, Canterbury, UK (1992) 23. "Fluorinated proteins as new 19F MRI and MRS agents, V. D. Mehta, P. V. Kulkarni, R. P. Mason, A. Constantinescu, & P. P. Antich, Proc. Am. Chem. Soc., Washington, August (medi/166) (1992) 24. "The relationship of Oxygen Tension and Myocardial Mechanical Function: a 19F NMR study", H. P. Shukla, R. P. Mason, C. Storey, F. M. H. Jeffrey, & P. P. Antich, Circulation, 86 #2757 (1992) 25. "Tumor oxygen tension gradients: new evidence from 19F MRI of perfluorocarbons, R. P. Mason, P. Peschke, E. W. Hahn, A. Constantinescu & P. P. Antich, Proc. Radiat. Res. Soc., Dallas TX, 162 (1993) 26. "Tumor oxygen tension: a comparison of perfluorocarbon 19F nmr probes", H. P. Shukla, R. P. Mason, W. Rodbumrung, D. Shumaker & P. P. Antich, Proc. Radiat. Res. Soc., Dallas TX, 131 (1993) 27. "Glutathione: a novel nmr approach to measurement in vivo", G. Cha, R. P. Mason, G. H. Gorrie, A. Constantinescu & P. P. Antich, Proc. Radiat. Res. Soc., Dallas TX, 131 (1993) 28. "Tumor Oxygen Tension: Measurement Using OxygentTM as a 19F NMR Probe at 4.7 T". R. P. Mason & P. P. Antich.: Vth ISBS, (1993). 30. "Fluorinated Macromolecular Probes as Biosensors for Non-invasive Assessment of pH with Magnetic Resonance Spectroscopy". V. D. Mehta, S. Aravind, P. V. Kulkarni, R. P. Mason & P. P. Antich: J. Nucl. Med. 34 (5):124P, (1993). 31. "Fluorinated Vitamin B6 Analogs as Molecular Probes for Non-invasive Measurement of Cellular pH Using Magnetic Resonance Spectroscopy". V. D. Mehta, P. V. Kulkarni, R. P. Mason, S. Aravind, N. C. Goomer, A. Constantinescu, G. H. Gorrie, & P. P. Antich,: C & E News, June (1993). 32. "19F MR Characterization of Fluorinated Proteins and Relaxation Rate Enhancement with Gd-DTPA for Faster Imaging. V. D. Mehta, R. P. Mason, P. V. Kulkarni, P. Lea, A. Constantinescu, & P. P. Antich, ACS, Div. Nucl Chem. & Tech, (1993). 33. "Perfluorocarbone (PFC) als Messonden zur Erfassung des Sauerstoffpartialdruckes (pO2) in vivo". P. Peschke, R. P. Mason, E. W. Hahn & P. P. Antich, Z. Radiol. 147: 1037 (1993) 34. "Cardiac pO2 by 19F NMR: comparison of sequestered perfluorocarbon emulsions in the perfused rat heart", H. P. Shukla, R. P. Mason & P. P. Antich, Proc. SMRM, New York August (1993). 35. "Tumor Architecture and Physiology: a Chronological Approach using 19F 3D NMR Microscopy of Perfluorocarbons", R. P. Mason, A. Constantinescu, P. P. Antich, P. Peschke & E. W. Hahn, 2nd Heidelberg NMR Microscopy Meeting, September (1993). 36. "Tumor architecture: a chronological perspective using 19-F 3D MRI", R. P. Mason, P. Peschke, E. W. Hahn, A. Constantinescu & P. P. Antich, Proc. 1st SMR , Dallas, S12-059, (1994). 37. "Novel 19F MRI agents: imaging potential with polylysines", V. Mehta, R. P. Mason, P. Kulkarni & P. P. Antich, Proc. 1st SMR, Dallas, S12-060, (1994). 38. "A new selective MRI contrast agent, ferrioxamine -dermatan sulphate: improved enhancement of AT1 rat prostate carcinomas", E. Dadey, R. P. Mason, D. Ranney, J. Fareed, A. Constantinescu, H. Chen, J. Zadei & P. P. Antich, Proc. 1st SMR , Dallas, S11-057, (1994). 39. "Tumor architecture: a chronological view using 19F 3D MRI of perfluorocarbons"; R. P. Mason, P. Peschke, E. W. Hahn, A. Constantinescu & P. P. Antich, Proc. Radiat. Res. Nashville, May (1994). 40. "MRI staining: a novel approach to tumor architecture using perfluorocarbons; P. P. Antich, R. P. Mason, A. Constantinescu, P. Peschke, E. W. Hahn, Proc. Soc. Nucl. Med. 35(5), 216P (1994). 41. "Myocardial pO2: Quantitation of regional ischemia in the perfused rat heart using 19F MRI at 9.4 T", H. P. Shukla, R. P. Mason & P. P. Antich, SMR, 2nd Annual Meeting, San Francisco 383, (1994). 42. "A 19F chemical-shift selective Turbo-FLASH NMR technique for T1 and pO2 mapping of perfluorocarbons", M. E. Belleman, G. Brix, P. Peschke, R. P. Mason & W. J. Lorenz, SMR, 2nd Annual Meeting, San Francisco, 719, (1994). 43. "Trabecular architecture studies by 3D MRI microscopy in bone biopsies", P. P. Antich, M. Wessels, R. P. Mason, R. McColl, J. Zerwekh & C. Y. C. Pak, Am. Soc. Bone. Min. Res., 9, S327-B392 (1994). 44. "Fluorinated Biosensors for Non-invasive Assessment of pH with Magnetic Resonance Spectroscopy". V. D. Mehta, S. Aravind, P. V. Kulkarni, R. P. Mason & P. P. Antich, ACS, Washington, Aug. (1994). 45. "Tumor Oxygenation: Acute Modulation Detected by 19F NMR of Perfluorocarbons", R. P. Mason, P. P. Antich, A. Constantinescu, P. Peschke & E. W. Hahn, Proc. AACR Conf. "Basic and Clinical Aspects of Prostate Cancer, C-25, Palm Springs, Dec. (1994). 46. "Nicht-invasive Erfassung des Sauerstoffpartialdruckes (pO2) mittels 19F-TurboFLASH-MR-Bildgebung von Perfluorocarbonen (PFC)", P. Peschke, M. E. Bellemann, G. Brix, R. P. Mason, E. W. Hahn, Radiologie, 35 S229 (1995). 47. "Tumor oxygenation: modulation detected by 19FMR of perfluorocarbons", R. P. Mason, P. P. Antich, A. Constantinescu, P. Peschke & E. W. Hahn, P08-6, 186, Proc. 10th ICRR, Würzburg, August (1995). 48. "Intracellular pH measurement with 6-Fluoropyridoxol in the perfused rat heart using 19F NMR spectroscopy, S. Hunjan, R. P. Mason, V. D. Mehta, P. V. Kulkarni, S. Aravind, V. Arora & P. P. Antich, Proc. 3rd SMR, 3, 1933, Nice, August (1995). 49. "Vascular agents for magnetic resonance imaging: development of fluorinated macromolecules" V. D. Mehta, P. Kulkarni, R. P. Mason, A. Constantinescu & P. P. Antich, Proc. ACS Div. Medicinal Chemistry, MEDI 241 Chicago (1995). 50. "Mapping Tissue Oxygenation in Tumor-Bearing Rats: In vivo 19F NMR Imaging of Perfluorocarbons on a 1.5 Tesla Whole-Body MR System." M. E. Bellemann, G. Brix, P. Peschke, M. J. Eble, R. P. Mason & W. J. Lorenz. 1363 Proc. 4th ISMRM, New York, April (1996). 51. "Potential of 6-Fluoropyridoxol as 19F pH sensing agent for MRS", V. D. Mehta, P. V. Kulkarni, R. P. Mason, S. Hunjan, V. Arora, A. Constantinescu, & P. P. Antich, American Chemical Society, Orlando (1996). 52. "Regional Tumor Oximetry: 19F NMR Spectroscopy of Hexafluorobenzene", S. Hunjan, R. P. Mason, A. Constantinescu, P. Peschke, E. W. Hahn & P. P. Antich, ISMRM workshop on MR of Cancer Physiology and Metabolism, Baltimore August (1996). 53. "Three-dimensional multiple-quantum-filtered MRI of 23Na in vivo at 4.7 T", N. Bansal, R. Kalyanapuram, R. P. Mason, N. Seshan, P. Winter, High Field MR Meeting, Minnesota, March (1997) 54. "19F PBSR EPI of hexafluorobenzene reveals heterogeneity of regional tumor oxygen dynamics", R. P. Mason, S. Hunjan, D. Le, P. Peschke, E. W. Hahn, A. Constantinescu, B. R. Barker, and P. P. Antich, Proc. 5th ISMRM, I, 301, Vancouver, April 1997 55. "Three-dimensional triple-quantum-filtered 23Na imaging of the rat in vivo", R. Kalyanapuram, P. Winter, R. P. Mason, N. Bansal, Proc. 5th ISMRM, 2116, Vancouver, April 1997 56. "Innovative approaches to tissue oximetry: 19F NMR of perfluorocarbons" R. P. Mason, Proc. Whitaker Biomedical Engineering Conf., Snowbird UT, July '97 57. "Regional tumor oxygen tension: fluorine echo planar imaging of hexafluorobenzene reveals heterogeneity of dynamics", R. P. Mason, S. Hunjan, D. Le, A. Constantinescu, B. R. Barker, P. Wong, P. Peschke, E. W. Hahn and P. P. Antich, 10th International Conference on Chemical Modifiers of Cancer Treatment, Jan 1998 58. "19F NMR pH indicators: design, synthesis and evaluation of a series of fluorinated vitamin B6 analogs." S. He, R. P. Mason, S. Hunjan, V. D. Mehta, V. Arora, R. Katipally, P. V. Kulkarni, and P. P. Antich, ACS MEDI 023, Dallas March 1998 59. "Tumor transmembrane pH gradient measurement with 6-fluoropyridoxol by 19F NMR spectroscopy, S. Hunjan, R. P. Mason, S. He, A. Constantinescu, P. V. Kulkarni & P. P. Antich, ISMRM Sydney, 55, April 1998 60. "Development of novel 19F NMR pH indicators: synthesis and evaluation of a series of fluorinated vitamin B6 analogs", S. Hunjan, S. He, R. P. Mason, V. D. Mehta, V. Arora, R. Katipally, P. V. Kulkarni, P.P. Antich, ISMRM Sydney, 1892, April 1998 61. "Tumor transmembrane pH gradient and regional oxygen tension measured by fluorine magnetic resonance" R. Mason, S. Hunjan, S. He, A. Constantinescu, P. Peschke, E. Hahn, P. Antich, 17th International Cancer Congress, Rio de Janeiro, 207, August 1998 62. "6-Fluoropyridoxamine: a new indicator of myocardial transmembrane pH gradient." R. P. Mason, S. Hunjan, S. He, F. Cruz III, V. Arora, P. V. Kulkarni, P. P. Antich. AHA Dallas, PO87, November 1998 63. "19F EPI of regional oxygen tension dynamics in a human tumor (implanted in a mouse)" R. P. Mason, A. Constantinescu, S. Ran and P. Thorpe, ISMRM Workshop on Cancer in MR, 89, St. Louis, November 1998 64. "Regional Tumor Oxygen Tension and Blood Flow: correlation studies using 19F PBSR-EPI of Hexafluorobenzene" Y. Song, R. P. Mason, S. Hunjan, A. Constantinescu, E. W. Hahn, and P. P. Antich, ISMRM Workshop on Cancer in MR, 92, St. Louis, November, 1998 65. "Measurement of Tumor Oximetry: A Comparison between Near Infrared Frequency-Domain Spectroscopy and 19F NMR Spectroscopy of Hexafluorobenzene" K. L. Worden, Y. Song, R. P. Mason, and H. Liu, Proc SPIE, San Diego, 1999 66. "Tumor oxygenation and measurement of regional dynamic changes" R. P. Mason, S. Hunjan, A. Constantinescu, Y. Song, E. W. Hahn, P. P. Antich, C. Blum and P. Peschke, Proc. AACR workshop on Molecular Determinants of Sensitivity to Anti-tumor Agents, Whistler, March 1999 67. "Tumor oximetry: comparison of 19F mr epi and electrodes" R. P. Mason, S. Hunjan, A.Constantinescu, Y. Song, D. Zhao, E. W. Hahn, P. P. Antich, and P. Peschke. Proc 27th ISOTT Dartmouth, NH Aug 1999 68. "Oxygenation in a human tumor xenograft: manipulation through respiratory challenge and anti-body directed infarction" R. P. Mason, A. Constantinescu, S. Ran & P. E. Thorpe. Proc 27th ISOTT, p43, Dartmouth, NH Aug 1999 69. "Tumor Oxygen Dynamics: Comparison between 19F MR-EPI of hexafluorobenzene and Frequency Domain NIR Spectroscopy" Y. Song, K. L. Worden, X. Jiang, D. Zhao, A. Constantinescu, H. Liu and R. P. Mason. Proc 27th ISOTT, Dartmouth, NH Aug 1999 70 “Investigation of tumor oxygen tension with respect to growth and respiratory challenge by 19F NMR EPI”, D. Zhao, A. Constantinescu, E. W. Hahn, and R.P. Mason, ISMRM, 623, Denver, April 2000 71. “Tumor oximetry: a comparison of the versatility of 19F MR EPI (FREDOM) and the fiberoptic “OxyLiteTM” R. P. Mason, D. Zhao, A. Constantinescu, and Andrew Obeid, ISMRM, 1040, Denver, April 2000 72. “Regional Tumor Tissue pO2 and Blood sO2: Comparison of 19F MR EPI and Frequency Domain NIR Spectroscopy” Y. Song; X. Jiang; D. Zhao; A. Constantinescu; H. Liu; and R. P. Mason, ISMRM, 1039, Denver, April 2000 73. “Tumor Oximetry: an enhanced dynamic mapping procedure using 19F echo planar MRI”, D. Zhao, S. Hunjan, A. Constantinescu, Y. Song, E. W. Hahn, P. P. Antich, and R. P. Mason, 47th Annual Radiation Research Meeting, P125, Albuquerque, May 2000 74. “A comparison of oxygen dynamics during respiratory challenge in two Dunning prostate tumor sublines having diverse Tpots”. D. Zhao, E. W. Hahn, A. Constantinescu, and R. P. Mason, 47th Annual Radiation Research Meeting, P113, Albuquerque, May 2000 75. “Regional tumor oxygen dynamics: relating tissue pO2 to the vasculature” Y. Song, X. Jiang, D. Zhao, A. Constantinescu, H. Liu, R. P. Mason, E11, Era of Hope Meeting, Atlanta, Jun. 2000 76. “Differential oxygen dynamics among the Dunning prostate R3327 rat tumor sublines with respect to growth and respiratory challenge”, D. Zhao, E. W. Hahn, A. Constantinescu, and R. P. Mason, #7 p25, Conference on Chemical Modifiers of Cancer Treatment, Banff, Oct. 2000 77. “Diverse approaches to monitoring oxygen dynamics in rat breast and prostate tumors” D. Zhao, Y. Song, H. Liu, A. Constantinescu, E. W. Hahn, and R. P. Mason, #19, p55, Conference on Chemical Modifiers of Cancer Treatment, Banff, Oct. 2000 78. “Positron Imaging of tumor angiogenesis using the biomarker [68Ga] deferoxamine-dermatan sulfate [68Ga:DF-DS]”, P. P. Antich, D. F. Ranney, P. V Kulkarni, A. Constantinescu, J. Fernando, R. Mason, E. Tsyganov, O. Oz, R. McColl, N. Slavine & R. W. Parkey, P-8, Soc. Nucl. Imaging in Drug Develop. Bethesda, Oct. 2000 79. “Differential oxygen dynamics among diverse Dunning prostate R3327 rat tumor sublines with respect to growth and respiratory challenge” D. Zhao, A. Constantinescu, E. W. Hahn, & R. P. Mason, II-24, Society for Basic Urological Research, Fort Myers, Nov. 2000 80. “Tumor vascular oxygen dynamics by near-infrared spectroscopy”, H. Liu, Y. Song, D. Zhao, A. Constantinescu, & R. P. Mason, Proc. SPIE. 4250, Optical Tomography and Spectroscopy of Tissue IV [4250-75] January 2001 81. “Prognostic Radiology: quantitative assessment of tumor oxygen dynamics by MRI”, D. Zhao, A. Constantinescu, E. W. Hahn & R. P. Mason, Proc. Transnational Research Program Workshop, RTOG semi annual meeting, Tampa, FL, p21, Feb 2001 82. “Brain tumor vascular dynamics: a BOLD MRI investigation” K. Fink, Z. Yetkin, R. McColl & R. P. Mason, #2087, Proc. 92nd AACR, New Orleans, Mar. 2001 83. “Comparison of tumor blood flow and oxygen dynamics in two diverse Dunning prostate tumor sublines”, D. Zhao, L. Jiang, A. Constantinescu, E. W. Hahn & R. P. Mason, #2088, Proc. 92nd AACR, New Orleans, Mar. 2001 84. “Evaluation of tumor oxygenation in the human brain”, Z. Yetkin, D. Mendelsohn, P. Purdy, R. McColl, & R. P. Mason, Proc. ISMRM, Glasgow, Apr 2001 85. “Measuring tumor oxygen dynamics predicts beneficial adjuvant intervention for radiotherapy in Dunning prostate R3327-HI tumors”, D. Zhao, A. Constantinescu, C. Chang, K. Gall, E. W. Hahn & R. P. Mason, Proc. 48th Annual Radiation Research Meeting, P21-265, San Juan, PR April 2001 86. “Insight into interdependent parameters of tumor blood flow and oxygenation”, D. Zhao, L. Jiang, A. Constantinescu, E. W. Hahn & R. P. Mason Proc. 48th Annual Radiation Research Meeting, P21-267,San Juan, PR April 2001 87. “Evaluation of Brain Tumor Oxygenation Using MR Imaging” Yetkin, Z., Mendelsohn, D., Purdy, P., McColl, R., Mason, R., Fullington, B., Clemons, R., Proc 39th ASNR #51, Boston April 2001
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