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Dawen Zhao Curriculum Vitae
Projective: Research Goals:
Employment:
09/03 –
Assistant Professor, Dept. Radiology, UT-Southwestern
Medical Center, Dallas TX
07/02-
Faculty
Graduate School Program of Advanced Radiological Sciences,
UT-Southwestern Medical
05/01-
08/03 Instructor,
Faculty member, Dept. Radiology, UT-Southwestern Medical Center, Dallas TX 02/99-04/01 Postdoctoral researcher, Dept. Radiology, UT-Southwestern Medical Center, Dallas TX Prize: 1.
Postdoctoral fellow stipend, 8th International Society
Magnetic Resonace in Medicine, Denver (Apr 2000)
2.
Junior
Investigator Award, 11th Tumor Physiology and Cancer Treatment
Conference, Banff (Oct 2000) Grant: 1. Department of Defence Prostate Cancer Research Program (PCRP) of the U.S. Army Medical Research and Materiel Command's Office of the Congressionally Directed Medical Research Program (grant #DAMD17-01-1-0180) (05/01-05/03). 2.
DOD Idea Award DAMD17-03-1-0363 (PI)
06/01/03-05/31/06 3. DOD Breast Idea Award BC043834
(Advisor)
03/01/05-02/29/08 4. DOD Prostate IDEA Award
PC050766
(Co-Investigator)
09/01/05-08/31/08 Memberships of Professional Society: Radiation Research Society American Association for Cancer Research
Publications:
7.
Zhao,
D.,
Constantinescu, A., Hahn, E. W., and Mason, R. P. Tumor oxygen dynamics
with respect to growth and respiratory challenge: investigation of the
Dunning prostate R3327-HI tumor. Radiat.
Res. 156, 510-20, 2001. 8.
Zhao,
D.,
Constantinescu, A., Hahn, E. W., and Mason, R. P.
Differential oxygen dynamics in the two Dunning prostate R3327 rat
tumor sublines (MAT-Lu and HI) with respect to growth and respiratory
challenge. Int. J. Radiat.
Oncol. Biol. Phys. 53, 744-56, 2002. 9.
Kim,
J. W., Zhao, D., Song, Y.,
Constantinescu, A., Mason, R. P., Liu H. Interplay of tumor vascular
oxygenation and tumor pO2 observed using NIRS, oxygen
electrode, and 19F MR pO2 Mapping. J.
Biomed. Optics.
8, 53-62, 2003. 10.
Zhao, D., Constantinescu, A., Hahn, E. W., and Mason, R. P. Measurement
of tumor oxygen dynamics predicts beneficial adjuvant intervention for
radiotherapy in Dunning prostate R3327-HI tumors. Radiat.
Res. Radiat. Res. 159, 621-31, 2003. 11.
Zhao, D., Ran, S., Constantinescu, A., Hahn, E. W., and Mason, R. P. Tumor
oxygen dynamics: in vivo MRI monitoring and correlation with histological
findings. Neoplasia 5, 308-18, 2003. 12. Jiang, L., Zhao, D., Constantinescu, A., and Mason, R.P. Evaluation of an intrinsic contrast mechanism in rat prostate tumor vasculature: comparison of BOLD contrast and Gd-DTPA DCE imaging. Magn. Reson. Med. 51, 953-60, 2004. 13.Zhao, D., Jiang, L., and Mason, R.P. Measuring changes in tumor oxygenation. Methods Enzymol. 386, 378-418, 2004. 14.Zhao,
D., Jiang, L., Constantinescu,
A., Hahn, E.W., and Mason, R.P. Continuous low-dose (Metronomic)
chemotherapy on rat prostate tumors evaluated by magnetic resonance
imaging in vivo.
Neoplasia
7, 678-87, 2005. 15.Zhao, D., Jiang, L., Hahn, E.W., and Mason, R.P. Tumor physiological response to combretastatin A4 phosphate assessed by MRI. Int. J. Radiat. Oncol. Int. J. Radiat. Oncol. Biol. Phys. 62, 872-80, 2005. 16. Zhu, Y., Guignard, F., Zhao, D., Liu, L., Burns, D.K., Mason, R.P. and Parada, L.F. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell. 8, 119-30, 2005. Sections of Edited Books: 1.
Kim, J. W., Song, Y., Zhao,
D., Constantinescu, A., Mason, R. P., Liu H. Interplay of tumor
oxygenation and pO2 in tumors using NIRS and Needle electrode. SPIE,
4250, 429-36, 2001. 2. Mason, R. P., Hunjan, S., Constantinescu, A., Song, Y., Zhao, D., Hahn, E. W., Antich, P. P., and Peschke+ P. Tumor oximetry: comparison of 19F MR EPI and electrodes. Oxygen Transport to Tissue XXIV. Proceedings of the 27th annual meeting of the International Society on Oxygen Transport to Tissue. (Dunn, J. F. and H. M. Swartz Eds.) Advances in Experimental Medicine and Biology 530, Kluwer Acad. New York, pp19-28, 2003. 3.
Song,
Y., Worden, K. L., Jiang, X., Zhao,
D., Constantinescu, A., Liu, H., and Mason, R. P. Tumor oxygen
dynamics: Comparison of 19F MR EPI and Frequency Domain NIR
Spectroscopy. Proceedings of the 27th annual
meeting of the International Society on Oxygen Transport to Tissue. (Dunn,
J. F. and H. M. Swartz Eds.), Advances in Experimental Medicine and
Biology 530, Kluwer Acad. New York, pp225-236, 2003. 4.
Kim,
J. W., Zhao, D., Mason, R. P.,
Liu H. Chemotherapeutic (cyclophosphamide) effects on rat breast
Abstracts
(Published Conference Proceedings): 1.
Song, Y., Worden, K. L., Jiang, X., Zhao,
D., Constantinescu, A., Liu, H., and Mason, R. P. Tumor oxygen
dynamics: Comparison of 19F MR EPI and Frequency Domain NIR
Spectroscopy. ISOTT, Dortmouth, 1999. 2.
Mason, R. P., Hunjan, S., Constantinescu, A., Song, Y., Zhao, D., Hahn, E. W., Antich, P. P., and Peschke+ P.
Tumor oximetry: comparison of 19F MR EPI and electrodes. ISOTT,
Dortmouth, 1999. 3.
Zhao,
D.,
Constantinescu, A., Hahn, E. W., Mason, R. P. Tumor oxygen dynamics with
respect to growth and respiratory challenge by 19F MR EPI.
p623, 8th ISMRM, Denver, Apr 2000. 4.
Mason,
R. P., Zhao,
D., Constantinescu, A., and
Obeid+, A. Tumor oximetry: a comparison of the versatility of 19F MR EPI (FREDOM) and the fiberoptic "Oxylite".
p1040, 8th ISMRM, Denver, Apr 2000. 5.
Song, Y., Jiang, X., Zhao, D.,
Constantinescu, A., Liu, H., and Mason, R. P. Regional Tumor Tissue pO2
and blood sO2:
Comparison of 19F MR EPI and frequency domain NIR spectroscopy. p1039, 8th ISMRM, Denver, Apr 2000. 6.
Zhao,
D.,
Hahn, E.W., Constantinescu, A., and Mason, R.P. A comparison of oxygen
dynamics during respiratory challenge in two Dunning prostate tumor
sublines having diverse Tpots. 47th Radia. Res. Soc.,
Albuquerque, Apr 2000. 7.
Zhao,
D.,
Hunjan, S., Constantinescu, A., Song, Y., Hahn, E.W. Antich, P.P. and
Mason, R.P. Tumor oximetry: an enhanced dynamic mapping procedure using 19F
echo planar MRI. 47th Radia. Res. Soc., Albuquerque, Apr 2000. 8.
Song, Y., Jiang, X., Zhao, D.,
Constantinescu, A., Liu, H., and Mason, R.P. Regional tumor
oxygen dynamics: relating tissue pO2 to the vasculature.
E11, Era of Hope Meeting, Atlanta, Jun 2000. 9.
Mason, R.P., Zhao, D.,
Constantinescu, A., Song, Y., Jiang, L., and Hahn, E.W. FREDOM (Fluorine
Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping): a
contexual review. ISMRM Workshop on MR in experimental and Clinical Cancer
Research in the New Millennium, Norway, Aug. 2000. 10.
Zhao,
D.,
Hahn, E.W., Constantinescu, A., and Mason, R.P. Differential oxygen
dynamics among the Dunning prostate
R3327 rat tumor sublines with respect to growth and respiratory
challenge. #7 p25, 11th International Conference of on Chemical
Modifiers of Cancer Treatment, Banff, Canada, Oct. 2000. 11.
Zhao,
D.,
Song, Y., Liu, H., Constantinescu, A., Hahn, E.W., and Mason, R.P. Diverse
approaches to monitoring oxygen dynamics in rat breast and prostate
tumors. #19 p55, 11th International Conference on Chemical Modifiers of Cancer
Treatment, Banff, Canada, Oct 2000. 12.
Zhao,
D.,
Constantinescu, A., Hahn, E.W., and Mason, R.P. Differential oxygen
dynamics among diverse Dunning prostate R3327 rat tumor sublines with
respect to growth and respiratory challenge. II-24, Society for Basic Urological Research, Ft. Myers, Nov 2000. 13.
Liu, H., Song, Y., Zhao, D., Constantinescu, A., and Mason, R. P. Tumor vascular oxygen
dynamics by near-infrared spectroscopy, Proc. SPIE. 4250, Optical
Tomography and Spectroscopy of Tissue IV [4250-75] Jan 2001. 14. Zhao, D., Constantinescu, A., Hahn, E.W., and Mason, R.P. Prognostic Radiology:
quantitative assessment of
tumor oxygen dynamics by MRI. Proceedings
of Translational Research Program Workshop, RTOG semi annual meeting,
Tampa, FL, p21, Feb 2001. 15.
Zhao,
D.,
Jiang, L., Constantinescu, A., Hahn, E.W., and Mason, R.P. Comparison of
tumor blood flow and oxygenation in two diverse Dunning prostate tumor
sublines. #2088 p388. 92th AACR. New Orleans, LA, Mar 2001. 16.
Zhao,
D.,
Jiang, L., Constantinescu, A., Hahn, E.W., and Mason, R.P. Insight into
interdependent parameters of tumor blood flow and oxygenation. #3 MS10. 48th
Radiat. Res. Soc. San Juan, Peurto Rico, Apr 2001. 17. Zhao, D., Constantinescu, A., Chang, K., Gall, K., Hahn,
E.W., and Mason, R.P. Measuring tumor oxygen dynamics predicts beneficial
adjuvant intervention for radiotherapy in Dunning prostate R3327-HI
tumors. #265 P21. 48th Radiat. Res. Soc. San Juan,
Peurto Rico, Apr 2001. 18.
Zhao,
D., Constantinescu,
A., Jiang, L., Chang, K., Gall, K., Hahn, E.W., and Mason, R.P. Prognostic Radiology: the
value of FREDOM. Proc.
EPR Viable Systems 9th International Meeting,
#S-8, Dartmouth, NH, Sep 2001. 19.
Zhao,
D., Jiang,
L., Constantinescu, A., Hahn, E.W., and Mason, R.P. In vivo MRI monitoring
of prostate tumor vasculature and oxygen dynamics. AACR New Discoveries
in Prostate Cancer Biology and Treatment, # B-56, Naples, FL, Dec
2001. 20.
Zhao,
D., Ran, S., Constantinescu, A., Hahn, E.W., and Mason, R.P. In vivo MRI monitoring
of tumor oxygen dynamics and correlation with histological findings. 4th
International Symposium on Anti-Angigenic Agents, Dallas, TX, Jan
2002. 21.
Jiang,
L., Zhao,
D., Constantinescu, A., Hahn,
E.W., and Mason, R.P. Assessment of tumor vasculature by comparison of
BOLD and Gd-DTPA contrast enhanced MRI in prostate tumors. 4th
International Symposium on Anti-Angigenic Agents, Dallas, TX, Jan
2002. 22.
Zhao,
D., Hahn,
E.W., Constantinescu, A., Ran, S., and
Mason, R.P. Comparison of hypoxia and microvascular density in the slow
growing well differentiated H vs. the faster growing anaplastic AT1
Dunning prostate R3327 rat tumor. 49th Radiat. Res. Soc.
Reno, NV, Apr 2002. 23.
Zhao,
D.,
Constantinescu, A., Chang, K., Gall, K., Hahn,
E.W., and Mason, R.P. Measurement of tumor oxygen dynamics correctly
predicts beneficial adjuvant intervention for radiotherapy in Dunning
prostate R3327-HI tumors. 10th ISMRM, Honolulu, Hawaii,
May 2002. 24.
Jiang,
L., Zhao,
D., Constantinescu, A., Hahn,
E.W., and Mason, R.P. Comparison of BOLD and Gd-DTPA contrast enhanced MRI
for the assessment of the two prostate tumor sublines exhibits different
vascular development. 10th ISMRM, Honolulu, Hawaii, May
2002. 25.
Zhao,
D., Ran, S., Constantinescu, A., Hahn, E.W., and Mason, R.P. MRI evaluation of
metronomic chemotherapy: the antitumor effects of combined low-dose
cyclophosphamide and thalidomide on prostate tumors. 8th
International Workshop on Tumor
Microenvironment and Its Impact on Cancer Therapies,
Pg V-3, Miami, FL, May 2003. 26.
Zhao, D.,
Constantinescu,
A., Peschke, P., Hahn, E.W., and Mason, R.P. Tumor oxygenation as an
indicator of aggressiveness. 8th International Workshop on
Tumor Microenvironment and Its Impact on Cancer Therapies, Pg II-4,
Miami, FL, May 2003. 27. Jiang, L., Zhao, D., Constantinescu, A., Hahn, E.W., and Mason, R.P. Assessing tumor vasculature by MRI: comparison of prostate tumor sublines known to exhibit different vascular development. 8th International Workshop on Tumor Microenvironment and Its Impact on Cancer Therapies, Pg II-6, Miami, FL, May 2003. 28.
Zhao, D.,
Constantinescu,
A., Hahn, E.W., and Mason, R.P. In vivo evaluation of metronomic
chemotherapy on prostate tumors by MRI. 10th Annual Cap Cure
Scientific Retreat, New York City, Nov 2003.
29.Zhao, D., Jiang, L., Constantinescu, A., Hahn, E.W., and Mason, R.P. Interrogation of tumor vasculature and oxygenation by integrated 1H and 19F MRI. 51st Radiat. Res. Soc. St. Louis, MO, Apr 2004.
30.Bourke, V., Gilio, J., Zhao, D., Constantinescu, A., Kodibagkar, V., Jiang, L., Hahn, E.W., and Mason, R.P. Correlation of Tumor Oxygen Dynamics with Radiation Response of the Dunning Prostate R3327-AT1 Tumor. 51st Radiat. Res. Soc. St. Louis, MO, Apr 2004.
31.Jennewein, M., Constantinescu, A., Bergner, O., Slavine, N., Seliouline, S., Lewis, M., Zhao, D., O’Kelly, S., Maus, S., Qaim, S.M., Tsyganov, E., Antich, P.P., Schirrmacher, R., Thorpe, P.E., Roesch, F., Mason, R.P. Radioactive Arsenic Isotopes: New Tools for the Imaging of Tumor Targeting Antibodies. Academy of Molecular Imaging, #150, Orlando, FL, Mar 2004.
32.Zhao, D., Jiang, L., Constantinescu, A., Hahn, E.W., and Mason, R.P. Evaluation of breast tumor microcirculation and oxygenation using a combination of BOLD, DCE and 19F MRI. 11th ISMRM, # 220, Kyoto, Japan, May 2004.
33.Bourke, V., Gilio, J., Jiang, L., Constantinescu, A., Zhao, D., Kodibagkar, V., and Mason, R.P. Further Validation of MR Oximetry as a Useful Prognostic Indicator of Tumor Radiation Response. 11th ISMRM, #2025, Kyoto, Japan, May 2004.
34.Jennewein, M., Constantinescu, A., Zhao, D., Lewis, M., O’Kelly, S., Maus, S., Antich, P.P., Schirrmacher, R., Qaim, S.M., Thorpe, P.E., Roesch, F., Mason, R.P. A new Labeling Method for Antibodies with Radioactive Arsenic Isotopes. European Association of Nuclear Medicin. Helsinki, Finland, Sep 2004.
35.Jennewein, M., Constantinescu, A., Bergner, O., Lewis,
M., Zhao, D., Slavine, N., Seliouline, S., O’Kelly, S., Maus, S., Qaim, S.M.,
Tsyganov, E., Antich, P.P., Roesch,
F., Mason, R.P., Thorpe, P.E. Molecular
Imaging of the Vascular Targeting Antibody Vatuximab® in Rat
Prostate Cancer. European Association of Nuclear Medicin.
Helsinki, Finland, Sep 2004. 36.
Zhao,
D., Jiang, L., Adam, A., Hahn, E.W., and Mason, R.P. Tumor
physiological response to
40. Zhao, D., Harper, A., Richer, E., Liu, Li., Slavine, N., Shay,
J. W., Antich, P. P., Mason, R. P. Novel 41.Zhao, D., Richer, E., Liu, Li., Ya Ren, Slavine,
N., Shay, J. W., Antich, P. P., Mason, R. P.
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